مفاهیم و مطالعات موردی در زیست‌شناسی شیمیایی ۲۰۱۴
Concepts and Case Studies in Chemical Biology 2014

1. Cover

2. Related Titles

3. Title Page

4. Copyright

5. List of Contributors

6. Introduction and Preface

7. Abbreviations

8. Chapter 1: Real-Time and Continuous Sensors of Protein Kinase Activity Utilizing Chelation-Enhanced Fluorescence

9. Chapter 2: FLiK and FLiP: Direct Binding Assays for the Identification of Stabilizers of Inactive Kinase and Phosphatase Conformations

10. Chapter 3: Strategies for Designing Specific Protein Tyrosine Phosphatase Inhibitors and Their Intracellular Activation

11. Chapter 4: Design and Application of Chemical Probes for Protein Serine/Threonine Phosphatase Activation

12. Chapter 5: Autophagy: Assays and Small-Molecule Modulators

13. Chapter 6: Elucidation of Protein Function by Chemical Modification

14. Chapter 7: Inhibition of Oncogenic K-Ras Signaling by Targeting K-Ras–PDEδ Interaction

15. Chapter 8: Development of Acyl Protein Thioesterase 1 (APT1) Inhibitor Palmostatin B That Revert Unregulated H/N-Ras Signaling

16. Chapter 9: Functional Analysis of Host–Pathogen Posttranslational Modification Crosstalk of Rab Proteins

17. Chapter 10: Chemical Biology Approach to Suppression of Statin-Induced Muscle Toxicity

18. Chapter 11: A Target Identification System Based on MorphoBase, ChemProteoBase, and Photo-Cross-Linking Beads

19. Chapter 12: Activity-Based Proteasome Profiling in Medicinal Chemistry and Chemical Biology

20. Chapter 13: Rational Design of Activity-Based Retaining β-Exoglucosidase Probes

21. Chapter 14: Modulation of ClpP Protease Activity: from Antibiotics to Antivirulence

22. Chapter 15: Affinity-Based Isolation of Molecular Targets of Clinically Used Drugs

23. Chapter 16: Identification of the Targets of Natural-Product-Inspired Mitotic Inhibitors

24. Chapter 17: Finding a Needle in a Haystack. Identification of Tankyrase, a Novel Therapeutic Target of the Wnt Pathway Using Chemical Genetics

25. Chapter 18: The Identification of the Molecular Receptor of the Plant Hormone Abscisic Acid

26. Chapter 19: Chemical Biology in Plants: Finding New Connections between Pathways Using the Small Molecule Sortin1

27. Chapter 20: Selective Targeting of Protein Interactions Mediated by BET Bromodomains

28. Chapter 21: The Impact of Distant Polypharmacology in the Chemical Biology of PARPs

29. Chapter 22: Splicing Inhibitors: From Small Molecule to RNA Metabolism

30. Chapter 23: Photochemical Control of Gene Function in Zebrafish Embryos with Light-Activated Morpholinos

31. Chapter 24: Life Cell Imaging of mRNA Using PNA FIT Probes

32. Chapter 25: Targeting the Transcriptional Hub β-Catenin Using Stapled Peptides

33. Chapter 26: Diversity-Oriented Synthesis: Developing New Chemical Tools to Probe and Modulate Biological Systems

34. Chapter 27: Scaffold Diversity Synthesis with Branching Cascades Strategy

35. Index

36. End User License Agreement