گیرنده وانیلوئید TRPV۱ در کشف دارو: هدف قرار دادن درد و سایر اختلالات پاتولوژیک ۲۰۱۰
Vanilloid Receptor TRPV1 in Drug Discovery: Targeting Pain and Other Pathological Disorders 2010

TRPV1 is considered an integrator of noxious stimuli andtherefore may be at a crossroads for pain transmission pathways.Because of its potential for managing multiple pain types,including osteoarthritis, chronic low back pain, neuropathic pain,and cancer pain, some consider it "the holy grail" of painmanagement. This dedicated reference summarizes available datarelated to the potential therapeutic utility for TRPV1 ligands.

With contributions from many of the world's leading experts onTRP channels, Vanilloid Receptor TRPV1 in Drug Discoverycovers the important TRPV1 target for drugs to treat painfulconditions such as inflammation, arthritis, and cancer pain. Thebook discusses:

• Recent advances in biology, chemistry, and pharmacology at boththe preclinical and clinical stage of the dynamic area of TRPV1drug discovery research

• The potential for drugs targeting TRPV1 in painful conditionssuch as inflammation, arthritis, and cancer

• The development of analgesic drugs

• Other applications for TRPV1, including the treatment ofrespiratory disease and diabetes

Featuring data relevant to the therapeutic potential of TRPV1and the medicinal chemistry involved in designing TRPV1antagonists, Vanilloid Receptor TRPV1 in Drug Discovery is akey tool for researchers in the pharmaceutical industry andacademia involved in pain, ion channels, and analgesic drugdevelopment.