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Preparative Chromatography for Separation of Proteins 2017

1. Cover

2. Title Page

3. Table of Contents

4. List of Contributors

5. Series Preface

6. Preface

1 Model‐Based Preparative Chromatography Process Development in the QbD Paradigm

2 Adsorption Isotherms

3 Simulation of Process Chromatography

4 Simplified Methods Based on Mechanistic Models for Understanding and Designing Chromatography Processes for Proteins and Other Biological Products‐Yamamoto Models and Yamamoto Approach

5 Development of Continuous Capture Steps in Bioprocess Applications

6 Computational Modeling in Bioprocess Development

7 Chromatographic Scale‐Up on a Volume Basis

8 Scaling Up Industrial Protein Chromatography

9 High‐Throughput Process Development

10 High‐Throughput Column Chromatography Performed on Liquid Handling Stations

11 Lab‐Scale Development of Chromatography Processes

12 Problem Solving by Using Modeling

13 Modeling Preparative Cation Exchange Chromatography of Monoclonal Antibodies

14 Model‐Based Process Development in the Biopharmaceutical Industry

15 Dynamic Simulations as a Predictive Model for a Multicolumn Chromatography Separation

16 Chemometrics Applications in Process Chromatography

17 Mid‐UV Protein Absorption Spectra and Partial Least Squares Regression as Screening and PAT Tool

18 Recent Progress Toward More Sustainable Biomanufacturing

25. Index

26. End User License Agreement