پیری انسان: از سازوکارهای سلولی تا راهبردهای درمانی ۲۰۲۱
Human Aging: From Cellular Mechanisms to Therapeutic Strategies 2021

Intro — Human Aging: From Cellular Mechanisms to Therapeutic Strategies — Copyright — Contents — Contributors — About the editors — Preface — Chapter 1: Aging and longevity: An evolutionary approach — 1.1. Introduction — 1.2. Why does aging occur? — 1.3. Mechanisms of aging — 1.4. Causality and chance in aging and longevity — 1.5. Conclusions and future perspectives — References — Chapter 2: Demographic aspects of aging — 2.1. Introduction — 2.2. Understanding the process: Browsing around the demographic transition theories — 2.3. Aging inequalities — 2.3.1. Differences by gender, education, and cause of death — 2.3.2. Does having a longer life also mean having a better life? — 2.3.3. Economics of population aging — 2.4. Conclusions and perspectives — References — Chapter 3: Pathobiology of aging: An introduction to age-related diseases — 3.1. Introduction — 3.2. Complexity — 3.3. Hallmarks of aging — 3.4. Genomic instability — 3.5. Epigenetic alteration — 3.6. Deregulated nutrient sensing pathways — 3.6.1. FOXO3 — 3.6.2. Insulin/IGF-1 pathway — 3.6.3. mTOR pathway — 3.6.4. Sirtuin pathway — 3.6.5. Autophagy — 3.7. Loss of proteostasis — 3.8. Mitochondrial dysfunction — 3.9. Telomere attrition — 3.10. Cellular senescence — 3.11. Stem cell exhaustion — 3.12. Altered intercellular communication — 3.13. Cancer and aging — 3.14. Conclusion and future perspectives — References — Chapter 4: Cellular senescence and senescence-associated secretory phenotype (SASP) in aging process — 4.1. Introduction — 4.2. Signaling pathway stimulating the appearance of SASP — 4.3. SASP components — 4.4. MiRNA and extracellular vesicles as new regulators and components of SASP — 4.5. SASP profile in different cell types — 4.6. Cellular senescence, SASP, and aging — 4.7. Conclusions and future perspectives — References.