LH-RH و آنالوگ های آن: جنبه های باروری و ضدباروری ۲۰۱۹
LH-RH and its Analogues: Fertility and Antifertility Aspects 2019

1. Opening remarks

2. Opening remarks

3. Contents

4. Physiological basis for clinical use of LH-RH and its analogues

5. Hypothalamic control of gonadotropin secretion and ovarian function

6. Induction of ovulation in amenorrhea infertile women with pulsatile administration of gonadotropin releasing hormone

7. Effects of different substituents in the A-ring of estradiol on its potency in sensitizing pituicytes to gonadotropin releasing hormone

8. Present status of LH-RH analog chemistry

9. Pharmacology of GnRH analogues

10. Binding sites for LH-RH in the human — does LH-RH exert extrapituitary actions in man?

11. Influence of LH-RH and des-Gly¹⁰ [D-Ala⁶]-LH-RH ethylamide on the biosynthesis of hCG in placental tissue culture

12. The pharmacologic profile of [(ImBzl)-D-His⁶,Pro⁹-NEt]-LH-RH (ORF 17070), an LH-RH agonist

13. Reversible pharmacologic castration of the female: implications for endometriosis, contraception and ovulation induction

14. Metabolism and pharmacokinetics of LH-RH agonists

15. Studies on controlled release systems for LH-RH analogues

16. Comparative reproductive pharmacology of LH-RH agonist and antagonist: contraceptive, therapeutic and safety aspects

17. Comparative non-human primate studies with LH-RH analogues

18. Long-term suppression of ovulation in the stumptailes macaque by active immunization against LH-RH or by LH-RH agonist administration

19. LH-RH agonists in the male: basic and clinical studies

20. A new approach to male contraception using combined androgen and GnRH analog treatment

21. LH-RH analog therapy of precocious puberty

22. Treatment of prostatic cancer with LH-RH analogues and control of therapy by cytology and DNA cytophotometry

23. Clinical experience (up to 40 months) with the LH-RH agonist Buserelin in the therapeutic approach to prostatic cancer

24. Antigonadal properties of LH-RH agonists: therapeutical applications in human

25. Contraceptive use of LH-RH agonists

26. LH-RH analogs and luteal function of the rhesus monkey

27. The effects of an LH-RH agonist on the premenstrual syndrome: a preliminary report

28. Discontinous intranasal application of the LH-RH analogon Buserelin in combination with an oral progestin in healthy female volunteers

29. Reversible down-regulation of pituitary-ovarian function induced by repetitive LH-RH agonist administration as a new approach for treatment and study of endometriosis in the human

30. The treatment of endometriosis with LH-RH agonists

31. Concluding remarks

32. List of First-mentioned Contributors